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AIDS
vaccines and
other infectious diseases
-with David Baltimore and Sally Blower
by Mary K. Miller
David Baltimore, from the
California Institute of Technology, is a famous scientist and head
of the effort to find an HIV vaccine. His press conference was jammed
with reporters waiting to hear the latest. Sally Blower, from the
University of California, San Francisco, was there too, talking
about her work developing models for the spread of drug resistance
for infectious diseases including HIV, herpes, and tuberculosis.
Science press conferences
are nothing like the counterparts you see on TV. If you're used
to seeing presidential press conferences, for instance, you wouldn't
recognize the gentile AAAS news briefings. For one thing, there's
not sea of microphones and the reporters don't yell out their questions.
Although they sometimes ask pointed queries, they're almost always
focused on the researchers work, not on personal lives or foibles.
These conferences are also
international in flavor. We met British, German, Dutch, Mexican,
Swiss, and Canadian reporters that work for newspapers, magazines,
TV stations, and the web. They're using a variety of devices from
pen and paper, to tape recorders, cameras, and computers.
The questions are the best
part of these briefings. It seems that the journalists know as much
about the science as the researchers. Everyone's on a first-name
basis, especially someone as media savvy as David Baltimore. You
can hear for yourself in the accompanying short audio clips.
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Dr.
David Baltimore outlines a more experimental approach to AIDS
research.
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Image
s
and Scientific Understanding
by Rob Semper
As you pass the various
meeting rooms at the AAAS annual conference, you can't help but
notice the large screens at the front of each room filled with strange
and unusual images of the world. These images, coming from the scientists'
slides, videotapes, and computers, offer a glimpse of the world
that is often invisible to the naked eye.
Advances in scientific
understanding are often tightly coupled to advanced instrument development.
And instrument development is often triggered by a search for scientific
understanding. The rapid development of new scientific visualization
tools is leading to amazing images that provide fundamental understanding
of the world. As Dr. Sean Carroll, researcher at the University
of Wisconsin says, "seeing does change everything."
This was nowhere more
apparent than at the session titled "Imaging Development: From Single
Cells to Complex Organisms." One of the major difficulties in understanding
the biology is making sense of how the genetic and molecular level
interacts with individual cells and the entire organism. Through
the use of recently developed visualization tools, researchers are
getting a new look at the process of embryo development. While it
is easy to look at organismal processes in visible light with microscopes,
seeing the microscopic molecular and dynamic cellular processes
is something else altogether. The papers in this session all presented
a tour de force use of visualization to explore different parts
of the development process.
By using fluorescent dyes
that attach themselves to specific molecular sites, the normally
invisible molecular events that drive the pattern development in
a butterfly embryo can be seen. New light microscopy techniques
and miniaturized magnetic resonance imaging (MRI) systems provide
structural and dynamic information about the development of the
mouse embryo. These techniques are part of a world of visualizations
that is exploding.
These images, with their
colored stripes, glowing spots, and roiling cells are unlike any
I've seen before. As the research advances, the forms and the understanding
they provide will doubtless be different. What is striking about
these images is not only the new information that they provide,
but their profound beauty. As usual, nature is constantly surprising
us with its infinite variety of form and function.
Where
did we come from?
By Mary K. Miller
In a session on the origins
of modern humans, organizer Loring Brace from the University of
Michigan-Ann Arbor said it's time to stop picking on the Neanderthals.
These earlier humans are commonly portrayed as thick-browed, non-speaking
brutes that survived through brawn rather than brains. The branch
of early humans called Homo sapiens, our direct ancestors, were
more delicate, with thinner bones, weaker joints and smaller teeth.
These weaker humans didn't need their bare hands to kill prey, like
the Neanderthals could do, because they developed language, a social
structure that allowed them to hunt in groups, and deadly throwing
weapons that could kill large prey from a safer distance. For thirty
years Professor Brace has been the champion of Neanderthals, claiming
they weren't so different than we are today. The physical differences
in the body and head could have evolved gradually over time, he
says, with a new branch of humans developing from the Neanderthals.
His theory of human origins hasn't caught on, Brace says, because
there's a long-standing prejudice against Neanderthals, a kind of
"neandro-phobia," that keeps people from considering that
they could be our ancestors.
John Shea from the State
University of New York has a slightly different take. He says we
should actually thank the Neanderthals for making us who we are:
social animals with sophisticated tools, able to give talks at scientific
meetings. Professor Shea is an archaeologist who studies the bones
and hunting tools of both Neanderthals and Homo sapiens that he
finds buried in present-day Israel. He says that the two groups
competed fiercely for food, much like today's lions and hyenas fight
over antelope in Africa. Sometimes the physically stronger Neanderthals
won and drove out Homo sapiens. But around 40,000 years ago, our
ancestors developed a spear with a thin point, a hunting technology
that gave them the ability to kill large game--and their competitors,
the pesky Neanderthals. Combined with their language skills and
social networks, Homo sapiens drove the Neanderthals out of their
way and moved into Europe. Eventually, the Neanderthals disappeared
altogether, leaving skinny spear throwers to populate the world.
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Dr.
John Shea discusses the effects of competition on the evolution
of weapon use in early humans.
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© 1999
The
Exploratorium
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